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Fig 1.

Flow diagram of recruitment of the participants.

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Fig 2.

Principle of visual NFB feedback.

Figure 2 depicts the underlying principle of NFB rewarding visual feedbacks. When NFB-rewarded selected EEG activity kept below reward threshold, online EEG graph was grey. As soon as amplitude of EEG activity was at least as high as reward threshold value, EEG graph got blue. Horizontal green line depicts reward threshold. Black line divided into 12 segments (each segment represents one second) (axis X) depicts time window. Axis y represents amplitude of EEG in pV (microvolt). Blue arrow in Y axis serves for manual adjustment of NFB reward threshold. 6.2 values next to axis Y (left side) indicates minimal value in pV which is necessary to be reached to get NFB feedback (blue EEG activity). 7.6 1.1V (the upper right quadrant indicates the average reward value within the current time window. 4 EEG1 -SMR is the title of this target online EEG graph predefined by NFB software Deymed Diagnostic (version 11).

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Table 1.

Score for fatigue before and after NFB measured by Fatigue Assessment Scale.

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Table 2.

Score for anxiety before and after NFB measured by Beck Anxiety Inventory.

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Table 3.

Score for depression before and after NFB measured by Beck Depression Inventory.

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Table 4.

Correlations between fatigue, anxiety and depression measured by Fatigue Assessment Scale, Beck Depression Inventory and Beck Anxiety Inventory.

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Table 5.

Correlated reductions of score of Fatigue Assessment Scale, Beck Anxiety Inventory and Beck Depression Inventory.

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Table 5 Expand