Fig 1.
Flowchart describing the methodology.
Fig 2.
Representation of familial T1DM cases.
Fig 3.
Pedigree illustration of families with more than 2 affected siblings.
Fig 4.
Clinical features observed in familial T1DM cohort.
a Age of onset of DM. b Gender distribution. c HbA1c at presentation in first Vs second affected sibling. d Age of onset in first Vs second affected sibling. e DKA at presentation in first Vs second affected sibling. f Celiac screen in the cohort. g Thyroid function and TPO status in the cohort. h Ethnicity.
Table 1.
TPO and Celiac autoantibody status in families with >2 affected siblings.
Fig 5.
Autoantibody status of sib-pair familial DM.
a Type of autoantibody present. b Number of autoantibodies present.
Table 2.
HLA alleles found in the cohort.
Table 3.
MODY gene variants present in at least 10% of the cohort.
Table 4.
Variants of unknown significance present in fam 8.