Table 1.
Characteristics of the study subjects at baseline.
Fig 1.
Determination of the cut-off value of baseline serum total bilirubin levels for predicting Progressive Renal Decline (PRD) by ROC curve.
The area under the curve (AUC) of receiver operating characteristic (ROC) analysis for progressive renal decline was 0.76, with sensitivity 0.80 and specificity 0.63, and the cut-off value of baseline serum total bilirubin levels were 0.5 mg/dL.
Table 2.
Multivariate logistic regression model predicting progressive renal decline (PRD).
Table 3.
Comparison in variables between two groups divided by the cut-off value of baseline serum total bilirubin levels.
Fig 2.
Comparison in renal endpoints between low bilirubin group (≤0.5 mg/dL) and high bilirubin group (>0.5 mg/dL) by Kaplan-Meier method and Cox hazard regression models showing the independence of baseline serum total bilirubin levels to predict renal endpoints.
(a) The cumulative incidence of composite endpoint (end-stage kidney disease or doubling of serum creatinine) levels by Kaplan-Meier method are shown at upper panel. Cox hazards regression model was used to analyze the independence of baseline serum total bilirubin levels to predict the composite endpoint, adjusted for age, gender, BMI, current smoker, HbA1c, the presence of hypertension, LDL-cholesterol, triglyceride levels, and baseline eGFR (shown at lower panel). (b) The cumulative incidence of 30% reduction in estimated glomerular filtration rate by Kaplan-Meier method are shown at upper panel. Cox hazards regression model was used to analyze the independence of baseline serum total bilirubin levels to predict 30% reduction in estimated glomerular filtration rate, adjusted for age, gender, BMI, current smoker, HbA1c, the presence of hypertension, LDL-cholesterol, triglyceride levels, and baseline eGFR (shown at lower panel). T. bil, serum total bilirubin level; HR, hazard ratio; BMI, body mass index; HbA1c, hemoglobin A1c; LDL cholesterol, low density lipoprotein cholesterol, eGFR; estimated glomerular filtration rate. SI con-version factors: to convert bilirubin to μmol/L, multiply by 17.104.