Fig 1.
Schematic diagram showing planned and actual implementation of the intervention (the HighSTEACS pathway).
Table 1.
Summary of all pre-specified primary and secondary analysis models.
Table 2.
Summary of all post-hoc advanced primary and secondary analysis models.
Table 3.
Summary of adjustment methods with justification.
Fig 2.
A: A forest plot showing pre-specified model results (geometric mean ratios and 95% confidence intervals) from the length of stay efficacy outcome analysis (including modifications to adjust for potential confounders). AFD = Adjusted for demographics, AMC = Adjusted for multiple covariates, APS = Adjusted for propensity score, IPTW = Inverse probability of treatment weighting. B: A forest plot showing advanced post-hoc model results (geometric mean ratios and 95% confidence intervals) from the length of stay efficacy outcome analysis (N = 31,477 for all). AFD = Adjusted for demographics, AMC = Adjusted for multiple covariates, APS = Adjusted for propensity score, IPTW = Inverse probability of treatment weighting.
Fig 3.
A: A forest plot showing log-odds ratio results and 95% confidence intervals from the pre-specified primary safety outcome analysis (including modifications to adjust for potential confounders). AFD = Adjusted for demographics, AMC = Adjusted for multiple covariates, APS = Adjusted for propensity score, IPTW = Inverse probability of treatment weighting. B: A forest plot showing advanced post-hoc model results (log-odds ratios and 95% confidence intervals) from the primary safety outcome analysis (N = 31,492 for all). AFD = Adjusted for demographics, AMC = Adjusted for multiple covariates, APS = Adjusted for propensity score, IPTW = Inverse probability of treatment weighting.
Fig 4.
Event rate for the primary safety outcome of myocardial infarction or cardiac death at 30 days by month of presentation from the start of the trial.