Table 1.
Demographic characteristics of the study population.
Fig 1.
Hippocampal subfields as segmented using the Freesurfer.
A) A transverse section of hippocampus displaying the different regions of the hippocampus, B) An illustration of the heterogenous hippocampus segmented into 12 subfields using an automated segmentation technique used in this study based on an atlas developed using Bayesian inference algorithm. CA—cornu ammonis, GCMLDG—granule cell layer of the dentate gyrus, HATA—hippocampus-amygdala-transition area.
Fig 2.
Hippocampal subfields exhibit asymmetric hemispherical effects for AD PGRS.
AD polygenic analysis on hippocampal subfields showed asymmetric hemispherical differences. Best fit AD polygenic risk score correlation P-values were shown for each hippocampal subfield. The x-axis shows hippocampal subfields and the y-axis shows–log10 P-values from the best-fit AD polygenic risk score correlations. The red-colored bar plot indicates the left hemisphere and the blue color indicates the right hemisphere.
Fig 3.
Hippocampal subfields in MCI and AD subjects show differential AD PGRS effects.
MCI and AD subjects exhibit differential AD polygenic effects for the hippocampal subfields. Best-fit AD polygenic risk score correlation P-values were shown for each hippocampal subfield stratified by cognitively normal (CN), mild cognitively impaired (MCI), and Alzheimer’s disease (AD) groups. Due to the low sample size for the AD group, MCI subjects were combined with AD subjects. The x-axis shows hippocampal subfields stratified for CN, MCI, and MCI+AD. The y-axis shows–log10 P-values from the best-fit AD polygenic risk score correlations. The orange-colored bar plot indicates CN, purple color indicates MCI, and red color indicates MCI+AD. A) The top bar plot represents the left hemisphere and the plot B) below represents the right hemisphere.