Table 1.
Search strategies used in each database to select articles to compose the systematic review, aiming to answer the question: What are the mechanisms of action of molecules with anti-TNF-α activity in the intestinal barrier?
Table 2.
PICO strategy used to select articles to compose the systematic review, aiming to answer the question: What are the mechanisms of action of molecules with anti-TNF-α activity on the intestinal barrier?
Fig 1.
Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) flowchart [13] of the articles included in the systematic review, aiming to answer the question: what are the mechanisms of action of molecules with anti-tnf-α activity on the intestinal barrier?
Table 3.
Data extracted from the studies that were selected to compose the systematic review.
Fig 2.
Assessment of the risk of bias of the studies included in the systematic review aiming to answer the question: What are the mechanisms of action of molecules with anti-tnf-α activity on the intestinal barrier?
The articles were evaluated based on the tool of the SYstematic Review Center for Laboratory Animal Experimentation (SYRCLE), developed by Hooijmans et al. [16].
Fig 3.
Schematic illustration of a hypothetical immune cell, presenting the main mechanisms discussed about the action of anti-inflammatory proteins and peptides with anti-TNF-alpha activity that act on the intestinal barrier.
The figure was built using the Servier Medical Art images (smart.servier.com). IFN: interferon, IL: interleukin; LBP: LPS-binding protein; LPS: lipopolysaccharide; TGF: transforming growth factor; TLR4: tool like receptor 4; TNF-α: tumor necrosis factor alpha; TNFR: tumor necrosis factor alpha receptor.