Fig 1.
Flowchart illustrating the search strategy used to identify association studies between genetic polymorphisms and COVID-19 disease.
Table 1.
Characteristics of studies included in the systematic review.
Table 2.
Meta-analyses of the association between polymorphisms in candidate genes and COVID-19 development and severity.
Fig 2.
Forest plots showing individual and pooled ORs (95% CIs) for the associations between the ACE1 Ins/Del (A), TMPRSS2 rs12329760 (B), and ApoE ε4 (C) polymorphisms and COVID-19 severity, under the allele contrast model.
Fig 3.
Forest plots showing individual and pooled ORs (95% CIs) for the associations between HLA alleles and COVID-19 presence or severity.
(A) Forest plot for HLA-A*30 and COVID-19 presence. (B) Forest plot for HLA-A*33 and COVID-19 severity. (C) Forest plot for HLA-B*38 and COVID-19 severity. (D) Forest plot for HLA-B*06 and COVID-19 severity. a Data from an Italian population; b Data from a Spanish population.
Fig 4.
Forest plots showing individual and pooled ORs (95% CIs) for the associations between the CCR5 rs333 (A) and ApoE ε4 (B) polymorphisms and COVID-19 presence, both under the allele contrast model.