Table 1.
Health states defined from the CLEAN-3 clinical study.
Fig 1.
Observed model structure from CLEAN-3 database (BDs strategy, SDs strategy)–Markov diagram.
BDs: Bundle of devices, SDs: Standard devices, PVC: Peripheral Venous Catheter.
Fig 2.
Evolution of a multi-state model.
As an example case study within the msm package, the process is observed, for instance, on four occasions (source: msm package [10]).
Table 2.
Number of catheters per patient—Statistical unit: The global patient with catheterization (alive, discharge or dead).
Table 3.
Input parameters considered in the cost analysis–For 1 patient-catheter (Euro 2022).
Table 4.
Costs items for Markov states and transitional events.
Table 5.
Costs per Markov states and transitional events (Euro 2022).
Table 6.
Cost-effectiveness results per patient from observed data (CLEAN-3 database)–Observed global patient–Hospital-time Horizon: 14 days—Base case scenario.
Table 7.
Cost-effectiveness results per patient-PVC-day from observed data (CLEAN-3 database)–Observed global patient–Hospital-time Horizon: 14 days–Base case scenario.
Table 8.
Cost-effectiveness results per patient from observed data (CLEAN-3 database)–Observed global patient–Scenario analysis 1.
Table 9.
Cost-effectiveness results per patient-PVC-day from observed data (CLEAN-3 database)–Observed global patient–Scenario analysis 1.
Table 10.
Cost-effectiveness results per patient from observed data (CLEAN-3 database)–Observed global patient–Scenario analysis 2.
Table 11.
Cost-effectiveness results per patient-PVC-day from observed data (CLEAN-3 database)–Observed global patient–Scenario analysis 2.
Fig 3.
Probabilistic sensitivity analysis: Cost-effectiveness plane for the base case analysis.
PVC: Peripheral Venous Catheter.