Fig 1.
Research design scheme. 230 individuals of Russian descent were genotyped and imputation was performed using an optimal reference panel. Furthermore, UK biobank (UKBB) GWAS results were used as a reference to build optimal polygenic risk models for 11 phenotypes. Explained phenotypic variance was compared with other populations.
Fig 2.
(A) Comparison of median imputation quality score for different minor allele frequency groups for HRC, 1000 Genomes and HGDP reference panels; HRC—Haplotype Reference Consortium, 1000G - 1000 Genomes project, HGDP—Human Genome Diversity Project. (B) Phenotypic variance explained in Japanese (BBJ), British (UKBB) and Russian (RUS) descent individuals using independent UK Biobank GWAS. (C) Principal Component Analysis (PCA) of 1000G, combined with Russian individuals (D) Concordance of allele frequencies between northwestern Russian (RUS), Central European from 1000G (CEU) and Great-Britain populations (UKBB). AF—alternative allele frequency, Grey—concordant variants, Red—discordant variants for northwestern Russians, Blue—discordant variants for Central Europeans, Dashed line—ideal concordance model, when allele frequencies of the first population totally match allele frequencies of the second population.