Fig 1.
This flowchart shows the parallel points of inclusion and exclusion across the two study cohort–including 1,081 (US) / 184,405 (Australia) cases with evidence of prior aortic valve replacement excluded from study analyses.
Table 1.
Baseline characteristics (US cohort).
Table 2.
All-cause mortality outcomes according to aortic stenosis severity.
Fig 2.
Adjusted all-cause mortality according to AS stage.
These adjusted Kaplan-Meier curves evaluate the risk of all-cause mortality over 10-years from the last echocardiogram according to AS severity in Australian (2A; left) and US (2B; right) cohorts when adjusting for age, sex, left ventricular ejection fraction, and presence of left heart disease.
Fig 3.
Fully adjusted all-cause mortality according to AS stage.
These adjusted Kaplan-Meier curves evaluate the risk of all-cause mortality over 10-years from the last echocardiogram according to AS severity in Australian (A) and US (B) cohorts when fully adjusting for all confounders (based on available data for each cohort.
Fig 4.
Risk of all-cause mortality according to clinical factors.
The forest plot denotes the risk of all-cause mortality occurring within 10 years across the full spectrum of AS when further adjusting for a comprehensive list of clinical factors.
Table 3.
Results of model 8: Sensitivity analysis reporting results for the relationship of as severity and cardiovascular-related death in the Australian cohort.
Fig 5.
Actual 5-year rates and odds ratios for all-cause mortality by AS stage stratified by left ventricular ejection fraction category.
This graph compares actual 5-year mortality (all-cause) associated with moderate AS versus the rest of the cohort when excluding all severe AS cases, according to LVEF quantified at the same time-point (last echocardiogram). Age and sex-adjusted odd ratios (95% CI) for mortality per group are shown above the bars (moderate AS group versus rest with *p<0.05, ** p<0.01 and ***p<0.001 for that group comparison) derived from multiple logistic regression. Actual 5-year mortality rates across the four LVEF subgroups (moderate AS versus rest) were—110/187 (58.8%) vs. 1427/4083 (34.9%), 81/211 (38.4%) vs. 851/3208 (26.5%), 171/585 (29.2%) vs. 1667/8038 (20.7%) and 452/1998 (22.6%) vs. 3230/19,599 (16.5%).
Fig 6.
Actual 5-year rates and odds ratios for cardiovascular-related mortality by AS stage stratified by left ventricular ejection fraction category.
This graph compares actual 5-year mortality (cardiovascular-related) associated with moderate AS versus the rest of the cohort when excluding all severe AS cases, according to LVEF quantified at the same time-point (last echocardiogram). Age and sex-adjusted odd ratios (95% CI) for mortality per group are shown above the bars (moderate AS group versus rest with *p<0.05, ** p<0.01 and ***p<0.001 for that group comparison) derived from multiple logistic regression. Actual 5-year cardiovascular-related mortality rates across the four LVEF subgroups (moderate AS versus rest) were—70/187 (21%) vs. 755/4083 (16%), 46/211 (21.8%) vs. 366/3208 (11.4%), 85/585 (14.5%) vs. 611/8038 (7.6%) and 191/1998 (9.6%) vs. 1049/19,599 (15.4%).