Table 1.
Demographics and characterization of study participants.
Fig 1.
Phagocytosis of Saccharomyces cerevisiae cells by pathogen-associated molecular pattern A) and opsonin receptors (B) by blood peripheral neutrophils in children. Groups: cystic fibrosis (CF) n = 6; cystic fibrosis plus chronic rhinosinusitis and presenting nasal polyps (CF+CRS with NP) n = 6; cystic fibrosis plus chronic rhinosinusitis but without nasal polyps (CF+CRS without NP) n = 5; control group (n = 14). In the top, % of neutrophils involved in phagocytosis, in the middle, number of yeasts ingested by neutrophils and in the bottom phagocytic index. Significant results are shown by bar between groups. Values are presented as the median, quartiles, maximum, and minimum values. KW = Kruskal-Wallis.
Fig 2.
Phagocytosis of Saccharomyces cerevisiae cells by pathogen-associated molecular pattern (A) and opsonin receptors (B) by blood peripheral monocytes in children. Groups: Cystic fibrosis (CF) n = 6; cystic fibrosis plus chronic rhinosinusitis and presenting nasal polyps (CF+CRS with NP) n = 6; cystic fibrosis plus chronic rhinosinusitis but without nasal polyps (CF+CRS without NP) n = 5; control group (n = 14). In the top, % of neutrophils involved in phagocytosis, in the middle, number of yeasts ingested by neutrophils and in the bottom, phagocytic index. Significant results are shown by bar between groups. Values are presented as the median, quartiles, maximum, and minimum values.
Fig 3.
Percentage of reduction of nitro blue tetrazolium by phagocytes obtained from peripheral blood of the control group (n = 14), cystic fibrosis group (CF; n = 5), cystic fibrosis + chronic rhinosinusitis with polyps group (CF+CRS with NP; n = 5), and cystic fibrosis + rhinosinusitis without polyps group (CF+CRS without NP; n = 6). Phagocytes were incubated with and without Saccharomyces cerevisiae yeasts to either stimulate or not stimulate superoxide anion production. Significant results are shown by * between groups. Values are presented as the median, quartiles, maximum, and minimum values.