Table 1.
Sample characteristics for discovery, replication, and non-discovery non-replication GWAS cohorts.
Fig 1.
Multi-population ideal health score discovery GWAS Manhattan plot (N = 142,404).
The negative log of the SNP p-value is plotted by chromosomal position (hg19) across the genome. Horizontal lines indicating genome-wide significant (p<5×10−8) and suggestive levels (p<1×10−5) are indicated by red and blue lines respectively. Transition between black and gray is used to define chromosome boundaries. Loci achieving genome-wide significance are annotated with the name of gene(s) in the region.
Table 2.
Multi-population meta-analysis results for ideal health score and results for top 17 SNPs from binary ideal health genome-wide association study (N = 142,404).
Table 3.
Discovery-replication results for top 17 SNPs from the ideal health score multi-population genome-wide association study.
Fig 2.
Multi-population PheWAS Manhattan plot: Ideal health score polygenic risk score vs disease phecode.
The negative log of the p-value is plotted for each of 882 disease phenotypes or “phecodes” with at least 200 cases and 200 controls in MVP. The horizontal red line indicates the statistically significant threshold (P < 5.67×10−5). Each color represents a disease category as defined on the x-axis. Loci achieving p<1×10−30 are annotated with the phecode description.
Table 4.
Logistic regression analysis of cardiovascular disease outcomes and mortality outcomes using ideal cardiovascular health or genetically-defined ideal cardiovascular health.
Table 5.
Cox regression and competing risk analysis of mortality outcomes.
Fig 3.
Two-sample Mendelian randomization results & forest plot.
The forest plot shows the OR and 95% confidence interval for each CVD outcome (CAD, HF, and IS). The table at the bottom of the figure describes the external consortia used for each outcome, along with the numbers of cases, controls, OR, and p-values. CAD = coronary artery disease; HF = heart failure, IS = ischemic stroke; OR = odds ratio; P = p-value; UKBB = UK Biobank; CARDIoGRAMplusC4D = Coronary Artery Disease Genome-wide Replication and Meta-analysis plus the Coronary Artery Disease consortium; HERMES = Heart Failure Molecular Epidemiology for Therapeutic Targets Consortium; ISGC = International Stroke Genetics Consortium.