Fig 1.
The SPIRIT schedule of enrolment.
aInformed consent may be obtained on the next day if it cannot be done on the day the subject is screened. bCollection of dynamic data items will continue until vancomycin treatment ends.
Fig 2.
popPK: population pharmacokinetic. HA: Hospital Authority.
Table 1.
Data items to be collected.
Fig 3.
Details of the Cs sampling schedule with respect to the dosing schedule.
Cs: serum vancomycin concentration. n: number of Cs measurements in the schedule. Note that the time separation requirements for peak, random, and trough Cs are only shown in the ideal sampling schedule. The same set of requirements applies for all proposed schedules with lower priorities.