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Fig 1.

PRISMA flow diagram.

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Table 1.

Tables of included randomised clinical trials.

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Fig 2.

Forest plot of the meta-analysis of chronic pain with 98% CI.

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Fig 3.

Forest plot of the meta-analysis of serious adverse events with 98% CI.

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Fig 4.

Forest plot of the meta-analysis of non-serious adverse events with 95% CI.

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Fig 5.

Forest plot of the meta-analysis of quality of sleep with 95% CI.

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