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Table 1.

An adapted version of the IWGDF classification system of diabetic foot ulcers.

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Table 1 Expand

Fig 1.

PRISMA flow diagram depicting study selection algorithm.

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Table 2.

Characteristics of all studies included in the review.

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Table 3.

Cut-off value, sensitivity, specificity, and AUC for ESR, CRP, PCT, and WCC for IWGDF grade 1 versus grade 2 diabetic foot ulcers.

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Table 3 Expand

Table 4.

Cut-off value, sensitivity, specificity, and AUC for ESR, CRP, PCT, and WCC for IWGDF grade 2 versus grade 3 diabetic foot ulcers.

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Table 4 Expand

Fig 2.

Erythrocyte sedimentation rate for differentiating between IWGDF grade 1 and grade 2 ulcers.

(A) sensitivity of ESR. (B) specificity of ESR. (C) AUC of ESR.

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Fig 2 Expand

Fig 3.

Erythrocyte sedimentation rate for diagnosing IWGDF grade 3 DFU.

(A) sensitivity of ESR. (B) specificity of ESR. (C) AUC of ESR.

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Fig 3 Expand

Fig 4.

C-reactive protein for the diagnosis of IWGDF grade 2 DFU.

(A) sensitivity of CRP. (B) specificity of CRP. (C) AUC of CRP.

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Fig 5.

C-reactive protein for differentiating IWGDF grade 3 ulcers from IWGDF grade 2 ulcers.

(A) sensitivity of CRP. (B) specificity of CRP. (C) AUC of CRP.

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Fig 5 Expand

Fig 6.

Procalcitonin for the diagnosis of infected DFU without osteomyelitis (IWGDF grade 2).

(A) sensitivity of PCT. (B) specificity of PCT. (C) AUC of PCT.

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Fig 7.

Procalcitonin for diagnosing diabetic foot osteomyelitis (IWGDF grade 3).

(A) sensitivity of PCT. (B) specificity of PCT. (C) AUC of PCT.

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Fig 7 Expand

Fig 8.

Usefulness of WCC for diagnosing IWGDF grade 2 ulcers.

(A) sensitivity of WCC. (B) specificity of WCC. (C) AUC of WCC.

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Fig 8 Expand

Fig 9.

White cell count for diagnosis of DFO (IWGDF grade 3).

(A) sensitivity of WCC. (B) specificity of WCC. (C) AUC of WCC.

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Fig 9 Expand

Fig 10.

Bar graph of sensitivity, specificity, and AUC of ESR, CRP, PCT and WCC for IWGDF grade 1 versus grade 2 ulcers.

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Fig 10 Expand

Fig 11.

Bar graph of sensitivity, specificity, and AUC of ESR, CRP, PCT and WCC for IWGDF grade 2 versus grade 3 ulcers.

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Fig 11 Expand