Fig 1.
(A) The 9 Early Treatment of Diabetic Retinopathy Study (ETDRS) grid including central macula 0.5 mm radius around the fovea (C), the inner superior (S1), inner inferior (I1), inner temporal (T1), and inner nasal (N1) regions (between 0.5 and 1.5 mm radius around the fovea) and outer superior (S2), outer inferior (I2), outer temporal (T2), and outer nasal (N2) regions (between 1.5 and 3.0 mm radius around the fovea) macular rings. (B) A representative OCT B-scan with segmentation of the inner limiting membrane and retinal pigmented epithelium layer (red lines). Green line marks the foveal centre.
Fig 2.
Sample size and reasons for exclusion from the data analysis in both the Raine Study and K-YAMS cohorts.
BRVO = branch retinal vein occlusion, ODD = optic disc drusen.
Fig 3.
Distributions of refractive errors (D) and axial lengths (mm) in the Raine Study and K-YAMS cohorts.
Table 1.
Demographic information of the study participants included.
Fig 4.
Estimated difference [and 95% confidence interval] in corrected and raw retinal thickness (μm) in (left) the Raine Study Gen 2 (mean axial length = 23.6 ± 0.9 mm) and (right) K-YAMS participants (mean axial length = 23.6 ± 1.1 mm).
Significant difference (p< 0.05) shown in bold, with red and green values representing underestimation and overestimation by the raw measurements, relative to the transverse magnification-corrected retinal thickness, respectively. Adjusted for sex and ethnicity. Note that the mean axial lengths of both cohorts are shorter than that assumed by the Spectralis SD-OCT (24.385 mm).
Fig 5.
Under- and overestimation of retinal thickness (μm) per 1mm increase in axial length by the raw measurements, relative to the transverse magnification-corrected thickness [and 95% confidence interval] in (left) the Raine Study Gen2 (mean axial length = 23.6 ± 0.9 mm) and (right) K-YAMS participants (mean axial length = 23.6 ± 1.1 mm).
Note that the mean axial length of both cohorts is shorter than that assumed by the Spectralis SD-OCT (24.385 mm). Significant interaction effects (p< 0.05) shown in bold and red (underestimation) or green (overestimation). Adjusted for sex and ethnicity.
Table 2.
Estimated difference in retinal thickness (μm) per 1mm increase in axial length.
Table 3.
The mean magnitude of the difference (in μm) and 95% confidence intervals (CI) in retinal thickness of myopes (spherical equivalent ≤ -0.50D), in comparison to non-myopes, based on the raw and corrected data from the Raine Study Gen2 and K-YAMS cohorts.