Fig 1.
Typical examples of fibril composition type A and type B, visualized by western blot.
A monoclonal antibody directed against TTR50-127 was used, which detects full-length TTR as well as the C-terminal fragments found in type A fibrils. Control = Cardiac tissue containing ATTR amyloid fibrils of type A.
Table 1.
Patients whose fibril type already had been determined in two biopsies.
Table 2.
Patients from whom a long-term follow-up biopsy was collected for this study.
Fig 2.
Duration and age, for patients whose fibril type already had been determined in two biopsies.
(A) Duration between the initial and subsequent biopsy, grouped according to fibril type. Horizontal lines represents the mean value ± standard deviation. (B) Age at initial and subsequent biopsy. The grey dashed line represents the age at disease onset (50 years old) which most often is used to determine a patient as “early or late onset”.
Fig 3.
Duration and age, for patients from whom a long-term biopsy was collected for this study.
(A) Duration between the initial and follow-up biopsy grouped according to fibril type. Horizontal lines represent the mean value ± standard deviation. (B) Age at the initial and the long-term follow-up biopsy. The grey dashed line represents the age at disease onset (50 years old) which most often is used to determine a patient as “early or late onset”.