Fig 1.
Subject timelines with patient and practice level dates used to derive start date (S), index date (I) and end date (E).
Lookback window (w) and at-risk follow-up period displayed.
Table 1.
Patient characteristics of the full cohort (W≥0) and four sub-cohorts selected by a minimum lookback window requirement.
Fig 2.
CPRD practice data contribution history for GP practices associated with the 1 million random patient sample, from up-to-standard date to date of last data collection.
The shaded region shows the follow-up period with the number of active practices by calendar year overlaid (right-hand y-axis).
Fig 3.
Standardised mortality ratio (SMR) and 95% confidence intervals by sub-cohorts selected by a minimum lookback window W≥w, over calendar year.
Reference line of SMR = 1 in red.
Fig 4.
Standardised mortality ratio (SMR) and 95% confidence interval by follow-up time-since-entry, in years.
Reference line of SMR = 1 in red.
Fig 5.
Standardised mortality ratio (SMR) by age group, over follow-up period in years.
Split to show initial high mortality rate trend (5a) and lower mortality rate after year 2 (5b). Reference line of SMR = 1 in red.