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Fig 1.

Gene selection using PGSA.

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Fig 1 Expand

Fig 2.

Pseudo code of gene selection using pyramid IBGSA.

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Table 1.

Characteristics and survival information for subgroups.

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Table 1 Expand

Table 2.

The overall accuracy of gene selection algorithms.

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Table 2 Expand

Fig 3.

Confusion matrix of optimization algorithms.

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Fig 4.

Accuracy (%) of PGSA during thirty independent runs.

The Y and X axes imply the accuracy and iteration respectively. The bubble size is correlated with the number of genes; the bigger the bubble, the higher the number of genes. The best model was reached at the 18th run with 84.5% accuracy and 73 genes.

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Fig 4 Expand

Table 3.

Five-fold cross-validated TPR, PPV, and F1-score of different algorithms.

The best result for each class has been bolded.

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Table 3 Expand

Fig 5.

Bottleneck subnetwork constructed based on PGSA selected genes in breast cancer.

Red and yellow colors indicate higher and lower bottleneck scores in the network, respectively.

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Fig 5 Expand