Fig 1.
In orange are shown the carbon atoms, blue the nitrogen atoms, yellow the sulphur atom, in cyan the fluorine atom and the polar oxygen and hydrogen atoms in red and white, respectively.
Fig 2.
Method structure of the study.
Fig 3.
SeDeM diagram for the calculated parameters (r).
Table 1.
Conversion factors to obtain “r values”.
Table 2.
Composition of tablet formulation expressed in mg per tablet.
Fig 4.
SEM of rosuvastatin calcium and selected excipients.
Fig 5.
DSC rosuvastatin calcium and selected excipients.
Fig 6.
DSC binary (1:1) mixtures of rosuvastatin and excipients.
(A) DSC of rosuvastatin, lactose monohydrate and physical mixture. (B) DSC of rosuvastatin, cellulose microcrystalline and physical mixture. (C) DSC of rosuvastatin, calcium phosphate and physical mixture. (D) DSC of rosuvastatin, PVPP and physical mixture. (E) DSC of rosuvastatin, magnesium stearate and physical mixture.
Fig 7.
TGA rosuvastatin calcium.
Fig 8.
FT-IR rosuvastatin calcium.
Fig 9.
FT-IR binary (1:1) mixtures of rosuvastantin and excipients.
(A) Physical mixture rosuvastatin and dibasic calcium phosphate. (B) Physical mixture rosuvastatin and lactose monohydrate.
Fig 10.
In red is shown the PXRD of pure rosuvastatin calcium, pink the PXRD of marketed tablets, blue the PXRD of mixture drug-excipients, green the PXRD of tablets under study.
Fig 11.
SeDeM rosuvastatin for the calculated parameters (r).
Table 3.
Parameters and tests used by the SeDeM method.
Table 4.
Pharmaceutical technological characteristics of rosuvastatin tablets.
Fig 12.
Dissolution rate of rosuvastatin calcium tablets.