Table 1.
Patient characteristics and peri- and postoperative data of the study cohort.
Fig 1.
A-C Serum creatinine values at day 7 after LuTx in patients without AKI and with AKI. According to the KDIGO-AKI stages (A) and the ADQI-AKI grading (B) and distribution of the AKI stages (C). Boxes and whiskers represent medians, lower and upper quartiles, and the extreme values. *p < = 0.05; **p < = 0.01; ***p < = 0.001. (D) Long-term mortality after LuTx. Kaplan-Meier curves were stratified by stages of AKI according to the KDIGO classification. No AKI vs. KDIGO-AKI stage 1, log rank p = 0.311; No AKI vs. KDIGO-AKI stage 2, log rank p = 0.573; No AKI vs. KDIGO-AKI stage 3, log rank p = 0.002; KDIGO-AKI 1 vs. KDIGO-AKI stage 2, log rank p = 0.176; KDIGO-AKI stage 1 vs. KDIGO-AKI stage 3, log rank p = 0.043; KDIGO-AKI stage 2 vs. KDIGO-AKI stage 3, log rank p = 0.017.
Table 2.
Hazard ratios of potential pre-, peri-, and postoperative factors for death in univariable Cox regression analysis.
Table 3.
Long-term prediction of all-cause mortality by multivariable Cox regression models with two AKI definitions (A and B) and d7/preHD-sCr (C).
Fig 2.
A-C. Calibration of the multivariable Cox models with KDIGO-AKI criteria (A), ADQI-AKI grading (B) and d7/preHD-sCr (C). Kaplan-Meier curves are shown for three separate risk groups ("low" to "high") as described in Methods. The table below shows the events observed in the three risk groups.
Fig 3.
Serum creatinine values at the last follow-up in the three risk groups assigned by the d7/preHD-sCr multivariable model.
For comparison, the d7/preHD-sCr value is also depicted for the three risk groups. For patients with dialysis, the serum creatinine level at initiation of renal replacement therapy was used. Boxes and whiskers represent medians, lower and upper quartiles, and the extreme values. *p < = 0.05; **p < = 0.01; ***p < = 0.001.
Fig 4.
Predicted and observed d7/preHD-sCr after LuTx.
Results were obtained by the multivariable regression model with pretransplant serum creatinine, diabetes, BMI and need of intraoperative ECMO as factors. Individual patient values and the regression line with the 95% confidence interval boundaries are shown.
Table 4.
Predictors of the d7/preHD-sCr after LuTx.