Fig 1.
Diagram depicting the number of articles found for the search strategies as established by the PRISMA guidelines.
Fig 2.
Compounds reported in the manuscripts reviewed.
Ten compounds were used as CRH-R1 selective antagonists, while only two compounds were used as CRH-R2. Three non-selective CRH-R antagonists were reported in the studies.
Table 1.
CRF administration models.
Table 2.
Stress models.
Table 3.
Chemical models.
Table 4.
Surgical models.
Fig 3.
Sex distribution in the animal studies.
Pie chart summarizing the percent of studies that included males, females or both sexes in their experiments. An over representation of males in the studies is evident.
Table 5.
Summary of clinical trials using CRH antagonists against disorders of the abdominal or pelvic area.