Fig 1.
Phenotyping algorithm to generate an All-CAD phenotype and CAD free controls along with 6 sub-phenotypes of CAD.
The algorithm is designed to be run either as a complete run as presented, or as modules taking each of the sections and running individually. Where incident and prevalent MI or CAD is present a choice can be made to designate either as prevalent or incident. ICD and related Codes used within each section are provided in Supplementary Tables.
Fig 2.
Overlap of self-reported diagnoses in UKB and those identified through EHR, for prevalent CAD or MI.
Venn diagram showing the overlap between UKB survey derived self-reported MI cases, self-reported CAD without MI cases and CAD or MI cases identified in EHR.
Fig 3.
Kaplan Meier survival analysis for of CAD phenotypes with all-cause mortality.
Panel A shows survival curves for participants identified to have an incident CAD and MI phenotype during follow up, with baseline recorded as the date of the clinical event. Panel B shows survival curves for participants identified as having prevalent CAD and MI phenotypes, with baseline recorded as date of enrolment.
Fig 4.
Coronary artery disease phenotypes and mortality.
Hazard ratios (HR) presented for all-cause mortality (95% C.I.) for CAD phenotypes; Adjusted for age and sex, compared to 465,155 CAD free controls (never or no CAD).
Fig 5.
Coronary artery disease phenotypes and association with polygenic risk score for CAD.
Odds Ratios (ORs) per 1 S.D. increase in CAD PRS, (95% C.I.) for CAD phenotypes; Adjusted for age and sex, compared to 378,025 CAD free controls (never or no CAD).