Table 1.
Criteria for study selection for review of natural history of ataxia-telangiectasia.
Fig 1.
PRISMA diagram.
Fig 2.
Number of cases per study.
Fig 3.
Family history of other illness, and presenting symptoms and signs.
Table 2.
Family history of ataxia-telangiectasia (A-T) in reported case of A-T.
Table 3.
Age of diagnosis of ataxia-telangiectasia as reported in literature.
Fig 4.
Ataxia, mobility, eye movements, oculomotor apraxia, and other neurological manifestations.
Fig 5.
Tone and weakness, movement disorders, cerebellar signs, immunoglobulin levels, immunoglobulin replacement, and prophylactic antibiotics.
Fig 6.
Age at start of prophylactic antibiotic and immunoglobulin replacement, non-infectious respiratory manifestations, and malignancy.
Fig 7.
Alpha fetoprotein (AFP), endocrine, bulbar telangiectasia, skin, and orthopaedic manifestations.
Fig 8.
Gastrointestinal, neuroimaging, cognitive and educational manifestations, and cause of death.
Table 4.
Age of death in ataxia-telangiectasia.