Table 1.
Components of the supplement and their mechanisms of action.
Fig 1.
CONSORT flow diagram.
Table 2.
Components in the supplement and placebo capsules.
Table 3.
Comparison of patients in groups 1 and 2 by sex, age, and disease duration.
Fig 2.
Total 7×7 questionnaire scores in group 1 and group 2 at visits 1, 2, and 3.
Fig 3.
Qualitative and quantitative composition of the intestinal microbiota genera in patients of groups 1 and 2 at visit 1.
Columns 2 and 3 present the relative bacterial content of a given genus (r.c., represents the normalized number of reads annotated to the current genus) averaged over all samples of a group. The color brightness reflects the average content, whereas the color hue (blue to orange) indicates the difference between the groups. The heatmaps in columns 4 and 5 show the bacterial content profiles of the genera for individual samples. The genera are sorted by a scoring factor, which reflects the magnitude of differences between groups 1 and 2, statistical significance (based on the Mann-Whitney test), and the average bacterial content across all samples.
Fig 4.
Relative content in the metagenome of genes involved in fatty acid biosynthesis (FAB) in patients of groups 1 and 2 at visit 1 (inferred from taxonomic data).
Columns 5 and 6 show the average content of FAB genes in each group. The heatmaps in columns 3 and 4 demonstrate the relative gene abundance per sample. Samples are re-arranged according to the similarity of gene abundance profiles.
Fig 5.
Statistically significant differences in the composition of intestinal microbiota genera between groups 1 and 2 at visit 3.
Columns 2 and 3 present the relative content (r.c.) of bacterial genera averaged over all samples in each group. The heatmaps in columns 4 and 5 show the bacterial content profiles for individual samples.
Fig 6.
The relative content in the metagenome of genes participating in FAB in patients of groups 1 and 2 at visit 3 (inferred from taxonomic data).
Columns 5 and 6 show the average content of FAB genes in each group. The heatmaps in columns 3 and 4 demonstrate the relative gene abundance per sample. The samples are re-arranged according to the similarity of gene abundance profiles.