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Fig 1.

Flow chart of case inclusion and exclusion from the JADER database.

AKI, acute kidney injury.

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Fig 1 Expand

Table 1.

Comparison of TW drug combination in cases with AKI and other ADEs.

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Table 1 Expand

Table 2.

The characteristics and TW drug combinations in target cases.

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Table 2 Expand

Table 3.

The parameters for the Weibull distribution for AKI cases by TW drugs combination pattern.

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Table 3 Expand

Fig 2.

The cumulative incidence with the number of TW drug combinations.

Median days indicate the date when the cumulative failure rate reached 50%.

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Fig 2 Expand

Fig 3.

The cumulative incidence with TW drugs in single drug groups.

Median days indicate the date when the cumulative failure rate reached 50%.

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Fig 3 Expand

Fig 4.

The cumulative incidence with TW drugs used in double drug groups.

Cases in which multiple TW drugs were started at the same time were excluded. Median days indicate the date when the cumulative failure rate reached 50%.

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Fig 4 Expand

Fig 5.

The cumulative incidence with the last TW drugs in the triple drug group.

Cases in which multiple TW drugs were started at the same time were excluded. Median days indicate the date when the cumulative failure rate reached 50%.

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Fig 5 Expand