Fig 1.
Flowchart of literature search.
Table 1.
Baseline characteristics of studies in meta-analysis comparing high TMB group with low TMB group in NSCLC patients receiving immunotherapy.
Table 2.
Baseline characteristics of studies in meta-analysis comparing immunotherapy with chemotherapy in NSCLC patients with high or low TMB.
Fig 2.
Forest plot for PFS of high-TMB versus low-TMB in NSCLC patients receiving immunotherapy.
PFS: Progression-free survival; TMB: Tumor mutational burden; NSCLC: Non-small cell lung cancer.
Table 3.
Subgroup analysis of immunotherapy efficacy for NSCLC in high TMB group versus low TMB group.
Fig 3.
Forest plot for OS of high-TMB versus low-TMB in NSCLC patients receiving immunotherapy.
OS: Overall survival; TMB: Tumor mutational burden; NSCLC: Non-small cell lung cancer.
Fig 4.
Forest plot for ORR of high-TMB versus low-TMB in NSCLC patients receiving immunotherapy.
OR: Objective response rate; TMB: Tumor mutational burden; NSCLC: Non-small cell lung cancer; OR: Odds ratio.
Fig 5.
Forest plots of meta-analysis of immunotherapy versus chemotherapy in NSCLC patients with high or low TMB.
(A) PFS in high-TMB patients; (B) PFS in low-TMB patients; (C) OS in high-TMB patients; (D) OS in low-TMB patients; (E) ORR in high-TMB patients; (F) ORR in low-TMB patients.