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Fig 1.

The entry procedure and study protocol.

Retrospective study (A) and prospective study (B) protocols are shown. LC, liver cirrhosis.

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Table 1.

The patients’ backgrounds and cox regression analyses in the retrospective study.

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Table 1 Expand

Fig 2.

The annual rate of change of the liver function indices and their association with the prognosis.

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Fig 2 Expand

Table 2.

The receiver operating characteristic analysis in the retrospective study.

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Table 2 Expand

Table 3.

The patients’ backgrounds and cluster analysis in the prospective study.

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Table 3 Expand

Table 4.

Univariate and multivariate logistic regression analyses in the prospective study.

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Table 4 Expand

Fig 3.

The translation of ALBI and CLDQ scores in the prospective study.

In the 16 cases of the cirrhosis progression group, the median ALBI score worsened from −2.08 to −1.78 (P < 0.001), whereas in the 30 cases of the non-progression group, the median ALBI score significantly improved from −2.15 to −2.43 (P < 0.001, A). Similar to the above, the median CLDQ score worsened from 5.3 to 4.9 (P = 0.034) in the cirrhosis progression group, whereas the median CLDQ score improved from 5.1 to 5.6 (P = 0.018, B) in the non-progression group. ALBI, albumin–bilirubin; CLDQ, Chronic Liver Disease Questionnaire. Error bar, standard deviation of each data.

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Fig 3 Expand