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Fig 1.

Schematic depiction of the experimental laser.

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Fig 2.

Integrating sphere configurations (a) positions for incident laser, sample, and detector, (b) transmission measurement, (c) reflection measurement, and (d) transmitted and reflected signals without sample.

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Fig 2 Expand

Fig 3.

The finite element geometry (a) model for skull, (b) mesh for skull, (c) model for skin, (d) mesh for skin.

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Fig 3 Expand

Fig 4.

Variation of the absorption coefficient and the reduced scattering coefficient with the laser power, (a) skull, (b) skin, (c) variation in the penetration depth for the skin and skull samples.

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Fig 4 Expand

Fig 5.

ROC curves of diffuse transmittance in skull (a) between 150 and 200mW, (b) between 200 and 225mW, (c) between 225 and 250 mW, (d) between 250 and 300 (e) between 300 and 350 mW, (f) between 150 and 350 mW.

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Fig 5 Expand

Table 1.

The obtained ROC curves parameters of skull and skin at different incident power.

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Table 1 Expand

Fig 6.

The estimated fluence rate distribution at the skull surface at (a) 150 mW, (b) 200 mW, (c) 225 mW, (d) 250 mW, (e) 300 mW, (f) 350 mW, and at the skin surface at (g) 150 mW (h) 200 mW (i) 225 mW (j) 250 mW (k) 300 mW (l) 350 mW.

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Fig 6 Expand

Fig 7.

(a) Changing the spatial diffuse reflectance with the anisotropy factor in skull, (b) Changing the spatial diffuse reflectance with the anisotropy factor in skin.

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Fig 7 Expand