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Fig 1.

PRISMA flow of studies included in review.

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Fig 1 Expand

Fig 2.

Risk of bias assessment for the RCTs completed.

Domains: D1: Bias arising from the randomization process; D2: Bias due to deviations from intended intervention; D3: Bias due to missing outcome data; D4: Bias in measurement of the outcome; D5: Bias in selection of the reported result.

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Fig 2 Expand

Fig 3.

Risk of bias assessment for the non-RCTs completed.

Domains: D1: Bias arising from the randomization process; D2: Bias due to deviations from intended intervention; D3: Bias due to missing outcome data; D4: Bias in measurement of the outcome; D5: Bias in selection of the reported result.

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Fig 3 Expand

Table 1.

Characteristics of studies included in the review.

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Table 1 Expand

Table 2.

Outcomes as reported in each study.

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Table 2 Expand