Fig 1.
Study diagram.
Fig 2.
T1 images are registered to the neonatal UNC Infant 012 Atlas and visually inspected for motion degradation. An automated rejection algorithm inspects and eliminates corrupted directions of DTI imaging, and deterministic tractography is performed to create white matter tracts. The connectome, a weighted undirected adjacency matrix between each of the 90 cerebral regions of interests (ROIs) is created, with average fractional anisotropy (FA) along the connecting tracts used as weights. Connection patterns are described using global graph theory metrics and individual tract connectivity is assessed.
Table 1.
Demographics.
Table 2.
Clinical characteristics.
Fig 3.
Neurodevelopmental outcomes in hypoxic-ischemic encephalopathy and congenital heart disease.
(A) Bayley-III scores at 12–18 months of age for cognitive, language, and motor domains. (B) Bayley-III scores at 30 months of age for cognitive, language, and motor domains. (C) Bayley-III sub scores for receptive and expressive language at 30 months of age.
Fig 4.
Global graph metrics in hypoxic-ischemic encephalopathy and congenital heart disease.
Boxplots and overlying scatter plots depict the medians, interquartile ranges, and individual data points for the following graph metrics: global efficiency, transitivity, modularity, and small-worldness.
Table 3.
Univariate analysis of 12-18-month neurodevelopmental outcomes.
Table 4.
Univariate analysis of 30 month neurodevelopmental outcomes.
Table 5.
Multivariate analyses of motor outcomes.
Table 6.
Language outcomes and neural pathways.
Fig 5.
Hypoconnected pathways and associated regions of interest in congenital heart disease.
After controlling for a false discovery rate and corrected gestational age at MRI, 18 weaker connections involving 22 ROIs were identified in CHD. The top 10 hypoconnections are listed, along with associated their test statistics. The top 6 ROIs most frequently involved in the hypoconnected pathways are also listed. A pictorial representation of the hypoconnections and associated ROIs is provided.