Table 1.
Patient demographics for all of the samples included in this study.
Fig 1.
Sectioned before (A) and after (B) RNA isolation showing persistent histologic features typical of LS to include dense subepithelial hyalinization with lichenoid lymphoplasmacytic infiltrate, thinning of the squamous epithelium with focal hyperkeratosis and attenuation of the basal layer.
Fig 2.
Hierarchical clustering analysis.
Hierarchical clustering analysis of the 26 samples included in the screening analysis using the 27 differentially expressed miRNAs (FDR<0.01) identified between LS and non-LS USD.
Table 2.
The median fold change (FC) in miRNAs expression observed in the validation analysis for LS specimens relative to non-LS specimens.
Fig 3.
The top eight differentially expressed miRNAs.
The top eight differentially expressed miRNAs between the LS and non-LS cohorts from the screening analysis. FDR<0.001 and a FC of <-2 or >2.
Fig 4.
Two-way hierarchical clustering of the significant gene ontology biologic processes, resulting from the analysis of the top eight differentially expressed miRNAs in the screening analysis. Clusters 1–4 include processes primarily involved in immunity and cluster 5 is comprised of processes related to wound healing. Log of P-values are depicted with greater significance in red.