Fig 1.
Flowchart of patients enrolled in the excited-UA study.
Abbreviations: FAS, full analysis set; PPS, per-protocol set.
Table 1.
Baseline characteristics (FAS analysis).
Table 2.
Changes in study endpoints in FAS analysis.
Table 3.
Safety endpoint.
Fig 2.
Serial changes of urinary 8-OHdG, L-FABP, osmolality and creatinine levels at weeks 12 and 24.
Values are mean ± standard deviation. For the changes in the values 24 weeks from baseline were assessed using the paired Student’s t-test in each group. For the difference between both groups analyzed using the unpaired t-test.
Fig 3.
Changes in NT-proBNP, LVEF, E/e’ (FAS), and TRPG (PPS) in each HFrEF and HFpEF patients.
Values are mean ± standard deviation. For the changes in the values 24 weeks from baseline were assessed using the paired Student’s t-test in each group. For the difference between both groups analyzed using the unpaired t-test. Abbreviations: HFrEF, heart failure with preserved ejection fraction; HFpEF, heart failure with preserved ejection fraction.
Fig 4.
Changes in urinary 8-OHdG, L-FABP and creatinine levels in each HFrEF and HFpEF patients (FAS).
Values are mean ± standard deviation. For the changes in the values 24 weeks from baseline were assessed using the paired Student’s t-test in each group. For the difference between both groups analyzed using the unpaired t-test.