Fig 1.
Overall flow chart of subtractive genomic against S. maltophilia.
This shows analysis of whole proteome of S. maltophilia (strain k279a).
Fig 2.
Summary for the detection of novel drug targets in S. maltophilia.
This shows protein counts of selected paralogous sequences, essential proteins, non-homologous proteins and drug target proteins.
Table 1.
Essential non-homologous proteins involved in 27 unique metabolic pathways.
Table 2.
Sub cellular localization prediction of proteins involved in unique metabolic pathways.
Table 3.
Drug-able target proteins analysed via DrugBank.
Fig 3.
Structure of the D-alanine-D-alanine ligase protein.
(A) Three dimensional structure of D-alanine-D-alanine ligase protein. (B) Ramachandran Plot of D-alanine-D-alanine ligase protein.
Fig 4.
Structure of the Acyl-[acyl-carrier-protein]—UDP-N acetyl glucosamine O-acyltransferase protein.
(A) Three dimensional structure of Acyl-[acyl-carrier-protein]—UDP-N acetyl glucosamine O-acyltransferase protein. (B) Ramachandran Plot of Acyl-[acyl-carrier-protein]—UDP-N acetyl glucosamine O-acyltransferase protein.
Fig 5.
2D and 3D interaction diagram of Acyl-[acyl-carrier-protein]—UDP-N acetyl glucosamine O-acyltransferase protein.
The structure shows complex with Enterodiol.
Fig 6.
2D and 3D interaction diagram of D-alanine-D-alanine ligase protein.
The structure shows complex with Rhazin.
Table 4.
The table displays the docking score and RMSD value for the compounds.
Table 5.
Results of inhibitors examined for Lipinski rule.
Table 6.
ADMET properties for compounds as predicted by admetSAR server.
Table 7.
Prediction of class and accuracy, organ toxicity, oral acute toxicity and genetic toxicity endpoints of candidate compounds.
Fig 7.
Graphical representation of predicted dose value distribution for Acyl-[acyl-carrier-protein]—UDP-N acetyl glucosamine O-acyltransferase protein.
In this graph, x-axis represents distribution of dose value and y-axis represents fraction of compounds.
Fig 8.
Graphical representation of predicted dose value distribution for D-alanine-D-alanine ligase.
In this graph, x-axis represents distribution of dose value and y-axis represents fraction of compounds.