Fig 1.
Two–by–two contingency table and calculation formula of ROR.
The two–by–two contingency table contains reports with the suspected drug, reports without the suspected drug, reports with the suspected AE, and reports without the suspected AE (a–d indicate numbers of reports). The ROR and 95% CI were calculated as shown.
Table 1.
Numbers of drug–AE pairs.
Fig 2.
Tendency of inducing all anticholinergic AEs (ALL) by each drug. (a) FAERS and (b) JADER.
Fig 3.
Tendency of inducing CNS anticholinergic AEs by each drug. (a) FAERS and (b) JADER.
Fig 4.
Tendency of inducing PNS anticholinergic AEs by each drug. (a) FAERS and (b) JADER.
Table 2.
(a) FAERS (b) JADER.
Table 3.
(a) FAERS (b) JADER.
Table 4.
(a) FAERS (b) JADER.
Fig 5.
Plots of drugs whose −log P is 308.
Drugs whose −log P is 308 and lnRORs are greater than 0 in FAERS: (a) ALL, (b) CNS, and (c) PNS. The size of the dots reflects the number of cases of each drug: It is “a+b” in the two–by–two contingency table. The color of the dots indicates the number of cases of anticholinergic AEs of the drug: It is “a” in the two–by–two table. Each dot is a drug, and the abscissa is the lnROR axis. The ordinate axis is the drug number by the descending lnROR.
Fig 6.
Comparison of Beers Criteria® anticholinergic drugs and other drugs.
These box plots show the distribution of the lnROR by the anticholinergic drugs and the other drugs. (a) FAERS and (b) JADER.
Fig 7.
Comparison of the lnROR between FAERS and JADER.
The lnROR of FAERS and JADER by each drug. Each line is a drug.