Fig 1.
Schematic graphs of OCT and OCTA parameters measurements, and best corrected visual acuity (BCVA) at baseline, at 48 hours after surgery, and at 1-year post-surgery.
Table 1.
Differences in OCTA, SD-OCT and BCVA before and each time point after surgery via endoscopic endonasal approach.
Fig 2.
Right eye of a healthy subject (48 years-old man) shows normal vessel density of the superficial capillary plexus (SCP) (A), deep capillary plexus (DCP) (A1), radial peripapillary capillary (RPC) plexus (A2), and foveal avascular zone (FAZ) area (A3) at Optical Coherence Tomography Angiography (OCTA). Right eye of a patient (51 years-old man) with pituitary adenoma before surgery reveals a reduction of vessel density in SCP (B), DCP (B1), RPC (B2) and an increase of FAZ area (B3) compared to healthy subject. At 48 hours after endoscopic endonasal surgery, a slight increase was found in vessel density of the SCP (C), DCP (C1), while a significant increase was shown in vessel density of the RCP (C2) compared to baseline. At 1 year of follow up a significant improvement of vessel density in macular and papillary regions was found compared to other time points (D-D2). FAZ area did not change over time (B3, C3, D3). Structural Spectral Domain OCT (SD-OCT) reveals normal thickness of the Ganglion Cell Complex (GCC) (A4) and Retinal Nerve Fiber Layer (RNFL) (A5) in right eye of the healthy control. The patient shows a focal reduction in GCC and RNFL (B4, B5) at baseline, a slight decrease in GCC (C4) and an absence of changes in RNFL (C5) at 48 hours after surgery. At 1 year of follow up a significant improvement was found in both SD-OCT parameters (D4, D5).
Table 2.
Multiple linear regression model between OCTA, SD-OCT and BCVA parameters at baseline and BCVA after surgery via endoscopic endonasal approach.