Table 1.
Cardiovascular, hormonal, and neural variables at normal model conditions and in the calibrated hypertensive virtual population (n = 60) before and after 1 month of baroreflex activation therapy.
Fig 1.
Baseline variables in the experimental (n = 6, shown in black from [22]) and virtual populations (both uncalibrated [n = 6,092 in red] and calibrated [n = 60, in green]) in three dimensions: Mean arterial pressure, plasma renin activity, and glomerular filtration rate.
Fig 2.
Responses to BAT in experimental [22] (Exp) and virtual populations.
Mean arterial pressure, glomerular filtration rate, and plasma renin activity were not significantly different between the two groups at baseline or after BAT.
Table 2.
Renal responses at normal model conditions and in the calibrated hypertensive virtual population before and after 1 month of baroreflex activation therapy.
Table 3.
Correlations among baseline variables and the change in mean blood pressure.
Fig 3.
Cardiovascular responses to BAT among control (BAT Control), RSNA Clamp, ANP Clamp, and ANP+RSNA Clamp simulations.
*p<0.05; #p<0.05 vs. baseline.
Fig 4.
Atrial natriuretic peptide (ANP), renal sympathetic nerve activity (RSNA), cardiac sympathetic nerve activity, and peripheral sympathetic nerve activity during 1 month of BAT in the control, RSNA Clamp, ANP Clamp, and ANP+RSNA Clamp simulations.
*p<0.05; #p<0.05 vs. baseline.
Fig 5.
Renin secretion and its determinants before and during BAT in the control, RSNA Clamp, ANP Clamp, and ANP+RSNA Clamp simulations.
*p<0.05; #p<0.05 vs. baseline.
Fig 6.
Changes in renal function during BAT in the control, RSNA Clamp, ANP Clamp, and ANP+RSNA Clamp simulations.
*p<0.05; #p<0.05 vs. baseline.