Table 1.
Summary of RCTs evaluating Vitamin C or HAT therapy (Hydrocortisone, Ascorbic Acid and Thiamine) in sepsis and septic shock.
Fig 1.
SPIRIT schedule including all trial relate procedures.
FiO2: Fraction if inspired Oxygen; PaO2: Partial Pressure of Oxygen; GCS: Glasgow Coma Scale; BP: blood pressure; HR: Heart Rate; RRT: Renal Replacement Therapy; SOFA: Sequential Organ Failure Assessment; ICU: Intensive Care Unit. * Only when a patient is admitted at the ED after 6 PM, it might be that screening and randomization will not take place on the same date. In that case screening will be performed on day 0. Otherwise both screening and randomization will be performed on the same day, being day 1. ** Concomitant medication: additional information about the administration of vasoactive agents, fluids and corticosteroids will be collected from day 1 to 5. This needs to be registered in different sections of the electronic Case Report Form. The only concomitant medication that needs to be specified are antibiotics and the medication used to treat potential adverse events. Continuation of home medication, pain medication thrombosis or ulcer profylaxis are not considered as concomitant medication.
Fig 2.
Patient Flow Chart.