Table 1.
Clinico-histopathological features among women seeking cervical cancer care at Kilimanjaro Christian Medical Centre (n = 145).
Table 2.
Association between clinico-histopathological features and protein expressions among women seeking care at Kilimanjaro Christian Medical Centre (n = 145).
Fig 1.
Nucleus and cytoplasm were positively stained for (a-b) p16 at 200x for cancerous and precancerous cervical lesion respectively. Nucleus positively stained for (c-d) TOP2A at 200x for cancerous and precancerous cervical lesion respectively, and (e) TOP2A at 40x for a benign cervical lesion. Nucleus and cytoplasm negatively stained for (f-g) p16 at 100x and 200x for cancerous and precancerous cervical lesion respectively, and (h) p16 at 200x for a benign cervical lesion. Nucleus negatively stained for (i-j) TOP2A at 200x for cancerous and precancerous cervical lesion respectively; (k-l) H&E staining at 100x and 40x for squamous cell carcinoma and normal cervix respectively.
Fig 2.
Distribution of p16 and TOP2A biomarkers expression across age-groups among women seeking care at Kilimanjaro Christian Medical Centre (n = 145).
The bold horizontal line within each column represents medians. Statistical significance is marked with double asterisks (Student’s t-test, p = 0.006) and ns stands for not significant.
Table 3.
Correlation matrix for p16 and TOP2A biomarkers expression with the histopathological factors among women seeking cervical cancer care at Kilimanjaro Christian Medical Centre (n = 139).
Table 4.
Diagnostic values of p16 and TOP2A immunohistochemistry in differentiating cancerous cervical lesions from benign and precancerous cervical lesions among women seeking cervical cancer care at Kilimanjaro Christian Medical Centre (n = 139).
Table 5.
Multivariate regression analysis and the strength of association between expression levels of p16 and TOP2A in differentiating cancerous cervical lesions from benign and precancerous cervical lesions among women seeking cervical cancer care at Kilimanjaro Christian Medical Centre (n = 139).