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Fig 1.

SPIRIT schedule of the trial.

T0: Pre-test data 4 hours prior to chemotherapy; T1: Immediate before 1st chemotherapy starts; T2: Immediate after 1st chemotherapy; T3: Immediate before 2nd chemotherapy starts; T4: Immediate after 2nd chemotherapy. 1IVR: Immersive virtual reality; 2CSAS-C: The short form of the Chinese version of the State Anxiety Scale for Children’.

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Fig 1 Expand

Fig 2.

Flow diagram of trial design.

a blood pressure; b heart rate; c chemotherapy-induced nausea and vomiting; d immersive virtual reality.

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Fig 2 Expand