Fig 1.
Abbreviations: BSG: Guidelines from the British Society of Gastroenterology [9]; NICE: National Institute for Health and Care Excellence; ESsCD: European Society for the Study of Coeliac Disease guideline [8]; ESPGHAN: European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines [7].
Table 1.
Summary table of study characteristics.
Fig 2.
Summary graph of risk of bias.
Fig 3.
Sensitivity, specificity, and positive predictive values.
Meta-analysis results are shown per diagnostic indicator. Positive predictive values (PPVs) were calculated for a population with a CD prevalence of 1% (red dotted line) using the estimated sensitivities and specificities from the meta-analyses. Diagnostic indicators are ordered from high to low PPV per diagnostic indicator group. The area of the box size is proportional to the total number of participants.
Fig 4.
Subgroup analysis stratified by age group and CD diagnosis.
Stratified meta-analysis results are shown per diagnostic indicator. Positive predictive values (PPVs) were calculated for a population with a CD prevalence of 1% (red dotted line) using the estimated sensitivities and specificities from the meta-analyses. The area of the box size is proportional to the total number of participants.
Fig 5.
Sensitivity analysis restricting to cohort studies.
Sensitivity meta-analysis on study design. Positive predictive values (PPVs) were calculated for a population with a CD prevalence of 1% (red dotted line) using the estimated sensitivities and specificities from the meta-analyses. The area of the box size is proportional to the total number of participants.