Fig 1.
BSP neural network architecture diagram.
The BSP proprietary OSA detection algorithm was built using neural networks and trained with a dataset of 5,783 patients and 8,417 records of overnight sleep studies. (A) Respiratory event detection model containing 160, 80, and 20 neurons; (B) Total sleep time estimation model containing 160, 80, and 5 neurons.
Fig 2.
CONSORT flow diagram.
Table 1.
Summary of subject characteristics and PSG results.
Fig 3.
(A) Scatterplot comparing bAHI to PSG-AHI; (B) Scatterplot comparing bTST to PSG-TST. bAHI = Belun apnea-hypopnea index; PSG-AHI = polysomnography apnea-hypopnea index; bTST = Belun total sleep time; PSG-TST = polysomnography total sleep time.
Fig 4.
(A) Bland-Altman plot for bAHI vs. PSG-AHI; (B) Bland-Altman plot for bTST vs. PSG-TST. bAHI = Belun apnea-hypopnea index; PSG-AHI = polysomnography apnea-hypopnea index; bTST = Belun total sleep time; PSG-TST = polysomnography total sleep time.
Fig 5.
ROC curves for bAHI vs. PSG-AHI at PSG-AHI Cutoffs of 5, 15, and 30 events/h (N = 78).
ROC = receiver operator characteristic; bAHI = Belun apnea-hypopnea index; PSG-AHI = polysomnography apnea-hypopnea index.
Table 2.
Performance (mean with 95% CI) of bAHI at PSG-AHI cutoffs of 5, 15, and 30 (all subjects, N = 78).
Table 3.
Contingency table of OSA severity measured by PSG and BSP (all subjects, N = 78).
Table 4.
Performance (mean with 95% CI) of bAHI at PSG-AHI cutoff of 15 for subjects taking heart-rate affecting medicines and subjects with comorbidities.
Fig 6.
The combined diagnostic algorithm using STOP-Bang cutoff of 5 and bAHI cutoff of 15 events/h curtailed the need for further sleep testing by 61%.
bAHI = Belun apnea-hypopnea index. a This false negative case had a PSG-AHI of 17.6 events/h; b These two false positive cases had mild OSA with PSG-AHI ≥ 5 events/h.
Table 5.
Performance (mean with 95% CI) of STOP-Bang score of 5 at PSG-AHI cutoffs of 5, 15, and 30 (N = 78).
Table 6.
Performance (mean with 95% CI) of the combined approach using STOP-Bang cutoff of 5 and bAHI cutoff of 15 (N = 48).