Table 1.
Multiscale model parameter values.
Table 2.
Immune system parameter values.
Fig 1.
Variation of the variables for no treatment case with s = 1.3×104, c = 22.3, R0 = 0.733.
Hence R0<1 and E0 is stable. E0 = {1.3×106,0,0,0,0,0}. T0 = 0.6×107, I0 = 100, P0 = 400, V0 = 50, Z0 = 20, W0 = 20.
Fig 2.
Variation of the variables for no treatment case with s = 68225, c = 82.3, R0 = 1.043, A1 = 1.05, A2 = 1.049, A3 = 1.02, and A4 = 1.07.
Hence 1<R0<min(A1,A2) and E1 is stable. E1 = {6.54×106, 20108, 86603, 8608,0,0}. T0 = 0.9×107, I0 = 100, P0 = 100, V0 = 100, Z0 = 20, W0 = 20.
Fig 3.
Variation of the variables for no treatment case with s = 1.3×105, c = 22.3, R0 = 7.33, A1 = 1.005, A2 = 1.18 A3 = 36.08, and A4 = 0.204.
Hence A1<R0<A3 and E2 is stable. E2 = {1.29×107, 4620, 19897, 1000, 0,70}. T0 = 0.9×107, I0 = 100, P0 = 100, V0 = 100, Z0 = 20, W0 = 20.
Fig 4.
Variation of the variables for no treatment case with s = 1.3×105, c = 82.3, R0 = 1.99, A1 = 1.05, A2 = 1.049, A3 = 1.021, and A4 = 2.036.
Hence A2<R0<A4 and E3 is stable. E3 = {1.24×107, 22727, 98191, 9759, 197,0}. T0 = 1.9×107, I0 = 100, P0 = 100, V0 = 100, Z0 = 20, W0 = 20.
Fig 5.
Variation of the variables for no treatment case with s = 1.3×106, c = 22.3, R0 = 73.35, A1 = 1.005, A2 = 1.18, A3 = 36.08 and A4 = 2.036.
Hence R0≥max(A3, A4) and E4 is stable. E4 = {1.29×108, 22727, 98236, 1000, 226, 391}. T0 = 0.9×108, I0 = 2000, P0 = 200, V0 = 200, Z0 = 200, W0 = 250.
Fig 6.
Variation of the variables for medical treatment case with R0 = 0.733.
.
Fig 7.
Variation of the variables for medical treatment case with R0 = 1.043.
Fig 8.
Variation of the variables for medical treatment case with R0 = 0.733.
Fig 9.
Variation of the variables for medical treatment case with R0 = 1.99.
Fig 10.
Variation of the variables for medical treatment case with R0 = 73.35.
Fig 11.
Variation of the variables for the transformed model for no treatment case with s = 1.3×104, c = 22.3, R0 = 0.733.
Hence R0<1 and E0 is stable. E0 = {1.3×106,0,0,0}. T0 = 0.6×107, I0 = 100, P0 = 400, V0 = 50.
Fig 12.
Variation of the variables for the transformed model for no treatment case with s = 68225, c = 82.3, R0 = 1.043.
Hence R0>1 and E1 is stable. E1 = {6.54×106, 20108, 86603, 8608}. T0 = 0.9×107,I0 = 100, P0 = 100, V0 = 100.
Fig 13.
Variation of the variables for transformed model for medical treatment case with R0 = 0.733.
Fig 14.
Variation of the variables for the transformed model for medical treatment case with R0 = 1.043.