Fig 1.
Flow chart of the methodology for study selection.
Table 1.
Summary of analyzed articles.
Table 2.
Outcome measures found in included RCTs and their abbreviations.
Fig 2.
Graph showing the percentage of use of each outcome measure.
Abbreviations: 6MWT 6-minute walking test; TUG Timed up and go test; GSTP Gait spatio-temporal parameters; MSWS-12 Multiple sclerosis walking scale-12; BBS Berg balance scale; T25W Timed 25-foot walk; 10m 10-meter walking test; 2MWT 2-minute walking test; MSIS-29 Multiple sclerosis Impact Scale_29; FSS Fatigue severity scale; FIS/mFIS Fatigue impact scale/modified fatigue impact scale; EDSS Expanded disability status scale; DGI Dynamic gait index; MS-IM Muscle strength isokinetik measure; Ac Accelerometers; ABC Activities-specific balance confidence scale; MAS Modified Ashworth scale; VAS (pain) Visual analogic scale (pain); ROM Range of motion; VO2 peak oxygen uptake; FSST Four step square test; TBS Tinetti balance scale; QoL SF-36 Quality of life short form 36; MSQoL-54 Multiple sclerosis quality of life; SA Stabilometric assessment; MS-SS: Muscle strength static strength; FMSC Fatigue scale for motor and cognitive function; FRT Functional reach test; FES Falls efficacy scale; HRSD Hamilton rating scale for depression; HADS Anxiety and depression scale; MusiQoL Multiple Sclerosis International Quality of Life scale; PQH-9 Patient health questionnaire; MSSE Mini mental state examination; STS Sit to stand test; MSSS-88 Multiple sclerosis Spasticity Scale– 88; MRC Medical research council; MS-MD Muscle strength mechanical device; MS-LD Muscle strength lokomat device; WLT Working load in treadmill; DTI Diffusion tensor imaging; GNDS Guy’s Neurological Disability Scale; SSST Six spot step tests; mBEest Test Mini best test; CTSIB Test for sensory interaction and balance; 5MWT 5-minute walking tests; 3MWT 3-minute walking test; FAC Functional ambulatory scale; AI Ambulatory index; WHODAS 2.0 World health organization disability assessment schedule; SOT Sensory organization test; CPET Maximal cardiopulmonary exercise test; TST Timed stair test; MSFCS Multiple sclerosis functional composite; COPM Canadian occupational performance measure; FD Falls diary; PASAT Paced auditory serial attention test; SRT sit and reach test; FBS Fullerton balance scale; WE Wurzburger inventory; WHOQoL-Bref WHO quality of life-bref; RAND-36 Random 36 health survey; BDI Beck depression inventory; COPE Coping Orientation to Problem Experienced; WEI-MuS Wurzburg Fatigue Inventory for Multiple Sclerosis; FAB Frontal assessment battery; MSSS-88 Multiple sclerosis Spasticity Scale; QoL-EQD Euro quality of life; PDDS Patient Determined Disease Steps.
Fig 3.
Outcome measures used according to ICF (% of use).
Abbreviations: GSTP Gait spatiotemporal parameters; FSS Fatigue severity scale; FIS/mFIS Fatigue impact scale/modified fatigue impact scale; MS-IM Muscle strength isokinetik measure; VAS (pain) Visual analogic scale (pain); ROM Range of motion; VO2 peak oxygen uptake; MAS Modified Ashworth scale; SA Stabilometric assessment; MS-SS: Muscle strength static strength; MSC Fatigue scale for motor and cognitive function; MRC Medical research council; MS-MD Muscle strength mechanical device; MS-LD Muscle strength lokomat device; WLT Working load in treadmill; DTI Diffusion tensor imaging; MSSS-88 Multiple sclerosis Spasticity Scale– 88; WEI-MuS Wurzburg Fatigue Inventory for Multiple Sclerosis; MSIS-29 Multiple sclerosis Impact Scale_29; QoL SF-36 Quality of life short form 36; MSQoL-54 Multiple sclerosis quality of life; HRSD Hamilton rating scale for depression; HADS Anxiety and depression scale; MusiQoL Multiple Sclerosis International Quality of Life scale; PQH-9 Patient health questionnaire; MSSE Mini mental state examination; WHOQoL-Bref WHO quality of life-bref; RAND-36 Random 36 health survey; BDI Beck depression inventory; COPE Coping Orientation to Problem Experienced; FAB Frontal assessment battery; QoL-EQD Euro quality of life; 6MWT 6-minute walking test; TUG Timed up and go test; MSWS-12 Multiple sclerosis walking scale-12; BBS Berg balance scale; T25W Timed 25-foot walk; 10m 10-meter walking test; 2MWT 2-minute walking test; EDSS Expanded disability status scale; DGI Dynamic gait index; Ac Accelerometers; ABC Activities-specific balance confidence scale; FSST Four step square test; TBS Tinetti balance scale; FRT Functional reach test; FES Falls efficacy scale; STS Sit to stand test; GNDS Guy’s Neurological Disability Scale; PDDS Patient Determined Disease Steps; SSST Six spot step tests; Mini Best Test Mini best test; CTSIB Test for sensory interaction and balance; 5MWT 5-minute walking tests; 3MWT 3-minute walking test; FAC Functional ambulatory scale; AI Ambulatory index; WHODAS 2.0 World health organization disability assessment Schedule; SOT Sensory organization test; CPET Maximal cardiopulmonary exercise test; TST Timed stair test; MSFCS Multiple sclerosis functional composite; COPM Canadian occupational performance measure; FD Falls diary; PASAT Paced auditory serial attention test; SRT sit and reach test; FBS Fullerton balance scale.
Table 3.
Gait spatiotemporal parameters.
Fig 4.
How outcome measures were combined in studies.
Abbreviations: FSS Fatigue Severity Scale; FIS Fatigue impact scale; GSTP Gait spatio temporal parameters; Ms Muscle strength; MSIS Multiple sclerosis impact scale; QoLSF- 36 Quality of life short form 36; MSQoL-54 Multiple sclerosis quality of life 54; MSWS-12 Multiple Sclerosis Walking Scale-12; Minute walk 2-minute,3-minute, 5-minute and 6-minute walking Tests merged; Meters walk 10-meter walking test/Timed 25-foot walk test merged; TUG Timed Up and Go; BBS Berg Balance Scale.