Fig 1.
Correlations between factor scores of depressive and anxiety symptoms.
MDD = major depressive disorder, PD = panic disorder, SAD = social anxiety disorder, OCD = obsessive-compulsive disorder. MDD1 = cognitive/affective symptoms, MDD2 = somatic symptoms, PD1 = physical concerns, PD2 = cognitive concerns, PD3 = social concerns, OCD1 = hoarding, OCD2 = checking, OCD3 = ordering, OCD4 = neutralizing, OCD5 = washing, OCD6 = obsessing.
Fig 2.
The symptom-profile of patient clusters identified by GGMM (left panel) and the covariance symptom network estimated for each cluster (right panel).
The thickness of edges in the symptom networks reflects the values of covariances. MDD = major depressive disorder, PD = panic disorder, SAD = social anxiety disorder, OCD = obsessive-compulsive disorder. MDD1 = cognitive/affective symptoms, MDD2 = somatic symptoms, PD1 = physical concerns, PD2 = cognitive concerns, PD3 = social concerns, OCD1 = hoarding, OCD2 = checking, OCD3 = ordering, OCD4 = neutralizing, OCD5 = washing, OCD6 = obsessing.
Table 1.
Participants’ allocations to the Gaussian graphical mixture model (GGMM)-based clusters (N = 1,521).
Fig 3.
Partial correlation network estimated for each patient cluster.
Nodes represent symptoms, and edges represent partial correlations between them. The thickness of an edge reflects the absolute value of the regularized partial correlation. Blue and red edges represent positive and negative regularized partial correlations, respectively.
Fig 4.
Centrality indexes (standardized z-scores) calculated in each partial correlation network.
MDD = major depressive disorder, PD = panic disorder, SAD = social anxiety disorder, OCD = obsessive-compulsive disorder. MDD1 = cognitive/affective symptoms, MDD2 = somatic symptoms, PD1 = physical concerns, PD2 = cognitive concerns, PD3 = social concerns, OCD1 = hoarding, OCD2 = checking, OCD3 = ordering, OCD4 = neutralizing, OCD5 = washing, OCD6 = obsessing.
Fig 5.
Bridge centrality indexes (standardized z-scores) calculated in each partial correlation network.
MDD = major depressive disorder, PD = panic disorder, SAD = social anxiety disorder, OCD = obsessive-compulsive disorder. MDD1 = cognitive/affective symptoms, MDD2 = somatic symptoms, PD1 = physical concerns, PD2 = cognitive concerns, PD3 = social concerns, OCD1 = hoarding, OCD2 = checking, OCD3 = ordering, OCD4 = neutralizing, OCD5 = washing, OCD6 = obsessing.