Table 1.
Patient and lesion characteristics among M-Ca, SM-Ca, and Ad-Ca.
Fig 1.
Proportion of mucosal and submucosal invasive duodenal carcinomas according to tumor diameter.
Table 2.
The proportion of SNADC according to tumor location.
Fig 2.
The proportions of mucin phenotype depending on tumor location between submucosal invasive and mucosal carcinoma.
Submucosal invasive carcinoma, which was all located on oral-Vater, showed a gastric-type in eight lesions (73%), mixed type in two (18%), and null-type in one (9%). No lesions showed intestinal-type submucosal invasive carcinoma. In contrast, mucosal carcinomas were equally distributed between oral- and anal-Vater; furthermore, intestinal type was observed in eight lesions (67%) and gastric-type in four (33%).
Fig 3.
A representative case of a submucosal invasive carcinoma with gastric phenotype on oral-Vater.
(a) A 10-mm semi-pedunculated lesion with surface depression is observed on the oral side of the papilla of Vater in the second portion of the duodenum. (b) Macroscopic appearance of the resected specimen shows a clear depression on top of the protrusion. (c) Histological finding shows a well-differentiated adenocarcinoma with submucosal invasion (hematoxylin and eosin stain). Immunohistochemical staining reveals that the tumor cells in both the mucosal and submucosal layer are positive for MUC5AC (e) and MUC6 (f) and negative for MUC2 (d), CD10 (g), and CDX2 (h), revealing a gastric mucin phenotype.