Table 1.
Characteristics of subjects tested for SARS-CoV-2 infection in Mexico, comparing cases who were tested using qRT-PCR, rapid antigen tests and a combination of both.
Fig 1.
A) Number of rapid antigen tests per 100,000 population across different Mexican states. Figure also shows the percentage of rapid antigen tests amongst all SARS-CoV-2 tests administered in Mexico City and the rest of Mexico (B) and the curve of confirmed cases according to date from symptom onset in Mexico City and the rest of Mexico (C, D). Abbreviations: qRT-PCR: Reverse transcription polymerase chain reaction.
Table 2.
Overall diagnostic performance metrics of rapid antigen tests to detect SARS-CoV-2 infection compared to qRT-PCR in Mexico and stratification by region of testing, patient setting, comorbidity, age and days from symptom onset to evaluation.
Table 3.
Time-dependent area under ROC curves using inverse weighted probability with Cox regression for detection of SARS-CoV-2 infection, adjusted for age assessing the performance of rapid antigen tests compared to qRT-PCR at days 1, 3, 7, 10 and 15.
The table also shows the ability of qRT-PCR or rapid antigen tests to predict hospitalization, intubation and mortality related to COVID-19 at these different time points.
Fig 2.
Mixed effects logistic regression models assessing predictors of cases with false negative compared to true positive test results (A) and false positive compared to true negative test results (B) using qRT-PCR as reference tests. Abbreviations: qRT-PCR: Reverse transcription polymerase chain reaction; CKD, Chronic Kidney Disease; CVD: cardiovascular disease; COPD: Chronic Obstructive Pulmonary Disease; OR: Odds Ratio; 95%CI: 95% Confidence interval, ICU: Intensive Care Unit.
Fig 3.
Models assessing risk associated to confusion matrix categories in rapid antigen test results compared to qRT-PCR for COVID-19 outcomes including hospitalization (A), requirement for intubation (B), risk of adverse outcomes (C) and lethality (D). Abbreviations: qRT-PCR: Reverse transcription polymerase chain reaction; CKD, Chronic Kidney Disease; CVD: cardiovascular disease; COPD: Chronic Obstructive Pulmonary Disease; OR: Odds Ratio; HR: Hazard ratio; 95%CI: 95% Confidence interval; HC: Healthcare.