Table 1.
Estimated glomerular filtration rate (eGFR) equations.
Fig 1.
Flowchart of exclusion criteria.
Table 2.
Cohort characteristics, stratified by ethnicity.
Fig 2.
Density plots of GFR measurements, stratified by ethnicity.
(A) mGFR, (B) eGFR FAS equation, (C) eGFR LM Revised equation, (D) eGFR EKFC equation, (E) eGFR CKD-EPI adjusted for ethnicity correction factor, (F) eGFR CKD-EPI unadjusted for ethnicity, (G) eGFR MDRD adjusted, and (H) eGFR MDRD unadjusted.
Fig 3.
Density plots of the bias between each eGFR equation and mGFR, stratified by ethnicity.
(A) eGFR CKD-EPI adjusted for ethnicity correction factor, (B) eGFR CKD-EPI unadjusted for ethnicity, (C) eGFR MDRD adjusted, (D) eGFR MDRD unadjusted, (E) eGFR FAS equation, (F) eGFR LM Revised equation, (G) eGFR EKFC equation.
Table 3.
Estimated glomerular filtration rate (eGFR) equations bias, precision and accuracy compared with mGFR, stratified by ethnicity.
Fig 4.
Bland-Altman plots for eGFR equations compared to mGFR, stratified by ethnicity.
(White, Black) participants: (A, H) adjusted CKD-EPI, (B, I) unadjusted CKD-EPI, (C, J) adjusted MDRD, (D, K) unadjusted MDRD, (E, L) FAS, (F, M) LM Revised, (G, N) EKFC. x-axes show the mean between the mGFR and eGFR measurements ([mGFR+eGFR]/2) and y-axes show the differences between the mGFR and eGFR measurements. Units: ml/min/1.73m2. The central dashed line represents bias, and the dashed lines above and below represent the 95% limits of agreement.
Table 4.
Regression analysis for the association between ethnicity and mGFR to identify an ethnicity correction factor for our study sample, adjusted for age, sex and log(SCr).
Table 5.
Linear regression analysis for the association between log(SCr) and ethnicity, adjusted for mGFR, age and sex.
Table 6.
Linear regression analysis for the association between the bias of CKD-EPI and MDRD equations and demographic characteristics in White participants, with mutual adjustment for all other variables in the table.
N = 1614.
Table 7.
Assessment of clinical impact of chronic kidney disease staging according to Kidney Disease Improving Global Outcomes (KDIGO) criteria using adjusted and unadjusted CKD-EPI-GFR equation in a cohort of people of self-reported ‘Black Ethnicity’ receiving nephrology care in the United Kingdom (excluding patients receiving dialysis).
Table 8.
Studies of measured and estimated glomerular filtration rate in Africa and Europe.