Fig 1.
Flow diagram showing the enrollment of study patients.
DENV, dengue virus; IPD, inpatient department; OPD, outpatient department.
Table 1.
Patients’ characteristics, dengue serotypes, and outcomes of plasma leakage status (n = 667).
Table 2.
Symptoms and signs of confirmed dengue by day of fever onset and plasma leakage status (n = 667).
Fig 2.
Changes in body temperature, hematocrit rise, and platelet count among confirmed dengue patients by combined day of fever onset.
(a) The higest body temperature (°C) by combined day of fever onset among patients with and without plasma leakage. (b). The higest hematocrit rise (%) by combined day of fever onset among patients with and without plasma leakage. (c). The lowest platelet count (×103/mm3) by combined day of fever onset among patients with and without plasma leakage. HCT, hematocrit; PL, plasma leakage; PLT, platelets; Temp, temperature.
Table 3.
Vital signs, cumulative fluid balance, and laboratory findings of confirmed dengue by days 1 to 4 of fever onset and plasma leakage status (n = 667).
Table 4.
Vital signs, cumulative fluid balance, and laboratory findings confirmed dengue patients by day 5 to 8 of fever onset and plasma leakage status (n = 667).
Fig 3.
Changes in aspartate aminotransferase, alanine aminotransferase, and serum albumin levels among confirmed dengue patients by combined day of fever onset.
(a) The highest level of AST (U/l) by combined day of fever onset among patients with and without plasma leakage. (b) The highest level of ALT (U/l) by combined day of fever onset among patients with and without plasma leakage. (c) The lowest level of serum ALB (g/dl) by combined day of fever onset among patients with and without plasma leakage. ALB, albumin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; PL, plasma leakage.
Table 5.
Categorical data of patients’ characteristics, clinical, and laboratory findings included in logistic regression analysis.
Table 6.
Univariate and multivariate logistic regression to determine independent risk factors associated with plasma leakage among dengue patients.
Fig 4.
Receiver operating characteristic curve of the plasma-leak score for predicting plasma leakage among dengue patients.
Table 7.
Multivariate logistic regression of a combined plasma-leak score for predicting plasma leakage.
Table 8.
Prognostic values of the plasma-leak score for predicting plasma leakage.