Fig 1.
Locations and muon flux parameters of the BNO ground laboratory and the DULB-4900 low-background laboratory in the Andyrchy mountain (data from [32]).
Table 1.
Components of radiation background in DULB-4900 and the ground laboratory in the institute building of BNO (INR, RAS).
Table 2.
Differentially expressed genes of the LB-flies vs. the NB-flies and corresponding biological processes or an activity based on the FlyBase annotation (FB2020_04 release).
FDR<0.05, LFC—Log2 fold change.
Fig 2.
Gene ontology biological process term enrichment analysis for up-regulated LB-flies genes.
Fig 3.
Gene ontology biological process term enrichment analysis for down-regulated LB-flies genes.
Fig 4.
Validation of the RNA-seq results by the RT-qPCR analysis.
The bar graphs represent the fold change in gene expression in the LB-flies vs. NB-flies. For all values p < 0.05.
Fig 5.
Diagram representing the quantity of shared genes for D. melanogaster developed in the low-background conditions of DULB-4900 and after different treatments: Irradiation with low (20 cGy), high (144 Gy) doses of ionizing radiation (a) and fungal treatment, spaceflight, chronic circadian misalignment (b).